The Differences Between Integral Peripheral Vs Surface Proteins

Last Updated on March 19, 2022 by QCity Editorial Stuff

Proteins are the major functional components of all living organisms and they can be classified as either integral or peripheral proteins. Integral proteins make up an organism’s cell and interact with other cellular components, while peripheral proteins interact with the environment. Surface protein is a type of protein that interacts with cells on the outer surface of an organism such as skin cells, intestinal lining, and blood vessels. The blog post will discuss what these different types of proteins do in an organism and how they affect our health.

There are many different types of proteins found in cells, and they can be classified based on their location. Integral peripheral proteins are located within the cell membrane, while surface proteins are found on the outside of the cell. Each type of protein has a specific function that contributes to the overall cellular process. In this blog post, we will discuss the differences between integral peripheral and surface proteins. We will also explore the functions of each type of protein and provide examples.

Comparison between Integral Peripheral and Surface Proteins

Parameters of Comparison  Integral PeripheralSurface Proteins
AnchoredIntegral proteins are not anchored to the membrane, they span itThe surface proteins are anchored to the membrane through a transmembrane domain
ExtracellularIntegral proteins do not have an extracellular loop and their cytoplasmic domains can be found in both intracellular and extracellular spacesSurface proteins have an extracellular loop that is exposed on the outside of the cell
LocatedSurface proteins are always located on one side of the membrane while integral ones can be found on either side or in both Surface protein receptors usually bind ligands that come from outside of cells while integrins mainly bind ligands that come from inside cells
Foundntegral peripheral protein is inside cellsSurface protein can be found on cell surfaces

What is Integral Peripheral?

For those who are new to the world of integrative medicine, Integral Peripheral is a form of treatment that focuses on treating both mind and body. This type of therapy can be effective in treating many chronic or acute conditions such as anxiety and depression, chronic pain, fibromyalgia, and more. Let’s explore this topic in greater detail so we can find out what it entails. 

Integral peripheral is one way to treat mental illness by combining traditional Western psychiatry with Eastern practices such as acupuncture or meditation. The idea behind integral peripheral is that the body’s organs may also affect how you think and feel because they all work together for balance within your physical self-and when there’s an.

Integral Peripheral Vs Surface Proteins

What are Surface Proteins?

What are surface proteins? Surface proteins are molecules that form the outermost layer of cells. This type of protein is responsible for recognizing other cells and aiding in cellular communication. Surface proteins also help protect our cells from bacteria, viruses, and other foreign substances. It is important to note that not all membrane-bound receptors are considered surface proteins because they can be found on intracellular membranes as well. But these types of molecules still play an important role in cell function by helping with signaling pathways or regulating ion channels. What this means is that without surface proteins, we could not sense physical stimuli like pain or touch nor respond to them appropriately. There would be no ability to communicate with our bodies or the outside environment either.

Surface proteins play a critical role in the structure and function of a cell’s plasma membrane. They are responsible for mediating cellular interactions, organizing protein complexes, and anchoring integral proteins to the lipid bilayer. In addition to their structural functions, surface proteins can also act as receptors or enzymes that catalyze biochemical reactions. Despite their important roles, relatively little is known about how surface proteins interact with one another and with the membrane lipids. researchers are working to unravel the mysteries of surface protein function in hopes of developing new therapeutic strategies for diseases caused by the dysfunction of these proteins.

Integral Peripheral Vs Surface Proteins

10 Differences Between Integral Peripheral and Surface Proteins

1. Surface proteins are found on the outermost layer of cells.

2. Integral peripheral proteins are found inside cells.

3. Surface proteins have a higher affinity for water than integral peripheral proteins do.

4. Integral peripheral proteins can be used to regulate cell growth, while surface protein is not involved in this process.

5. Integral peripheral proteins are more likely to transport substances across membranes and into or out of the cell, while surface protein only helps with maintaining the integrity of the membrane.

6. The structure and function of integrally-peripheral and surface protein molecules differ because they require different cellular environments and tasks to perform their functions.

7. Surface proteins are on the surface of a cell, whereas integral peripheral proteins are inside the cell.

8. Integral peripheral proteins usually have a role in transporting substances into or out of cells, while surface proteins usually function as receptors for external stimuli.

9. The shape and structure of an integral peripheral protein are more variable than that of a surface protein.

10. Integral peripheral proteins can be found anywhere in the body, but most often they’re located near organs such as kidneys or lungs.

Interesting Statistics or Facts of Integral Peripheral

1. The peripheral nervous system is composed of the nerves that connect the spinal cord to other parts of the body.

2. It contains sensory neurons, motor neurons, and interneurons which help with reflexes.

3. The spine has 31 vertebrae in total.

4. There are 12 pairs of ribs on each side of your ribcage for a total of 24 ribs.

5. Your brain sends messages through these nerves to control everything from breathing to swallowing.

6. A new neuron develops every second in humans until birth.

Interesting Statistics or Facts of Surface Proteins

1. Surface proteins are responsible for the majority of cellular recognition and adhesion.

2. The surface protein that is responsible for the immune system’s response to pathogens is called MHC Class II.

3. There are more than 2000 different types of surface proteins in the human body, with more being discovered every day.

4. A surface protein can be either a receptor or an adhesin, depending on its function.

5. Receptors recognize molecules outside the cell while adhesins bind to molecules inside or outside of cells.

6. Two examples of receptors would be Toll-like receptors (TLRs) which play a key role in innate immunity and TNF-alpha receptors which activate inflammation pathways in our bodies when they’re activated by cytokines.


Integral peripheral and surface proteins: Integral peripheral proteins are those that attach to the cell membrane. They provide scaffolding for other molecules to maintain their shape and function properly. Surface-bound proteins, on the other hand, help cells with adhesion as well as any necessary chemical functions such as signaling between cells or releasing chemicals outside of the cell.  Both integral peripheral and surface proteins play critical roles in keeping our bodies functioning at their best.

The world is full of proteins. Proteins are the largest class in life, and they have a wide variety of functions to help us live our lives every day. One way that scientists classify these diverse molecules is by their location on or near either the surface or inside an organism’s cells. Integral peripheral proteins are found only outside the cell membrane while surface proteins can be both external and internal depending on where it binds to other molecules like DNA and carbohydrates (exoskeleton). Surface protein also has many more interactions than integral peripherals which depend mostly on its shape for function. This blog post covered some basic information about protein classification as well as how different types of protein affect plant growth during photosynthesis. 


Resource 01:
Resource 02:

Scroll to Top